Scientific Poster: ThioBridge as a Tool for ADCs
Published on May 10, 2024
Access our recent poster from WADC London 2024 entitled: “ThioBridge as a Tool for the Design,
Optimization & Manufacture of ADCs”
Abstract
The ThioBridge conjugation technology makes use of naturally occurring interchain disulfide bonds of an antibody to generate antibody drug
conjugates (ADCs).
ThioBridge offers several key features including homogeneity with high conversion to a single DAR species, stability as the linker does not
deconjugate or cross-conjugate and site-specificity due to conserved location of conjugation.
Access the poster here
Poster authors include Richard J. Spears*, Ruslan Grygorash, Johanna Midelet, Gavin Birch, Bebiana Sousa, Ben Sawyer, Joao Nunes, William McDowell, Fabio Rossi, Nicolas Camper*, Robert Holgate,
Campbell Bunce
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