Journal Publication: The MHC Associated Peptide Proteomics Assay is a Useful Tool for the Non-Clinical Assessment of Immunogenicity

The propensity of therapeutic proteins to elicit an immune response poses a significant challenge in clinical development and safety of the patients. Assessment of immunogenicity is crucial to predict potential adverse events and design safer biologics.

In this recent study co-authored with the FDA, we employed MHC Associated Peptide Proteomics (MAPPS) to comprehensively evaluate the immunogenic potential of re-engineered variants of immunogenic FVIIa analog (Vatreptacog Alfa). Our finding revealed the correlation between the protein sequence affinity for MHCII and the number of peptides identified in a MAPPS assay and this further correlates with the reduced T-cell responses. Moreover, MAPPS enable the identification of “relevant” T cell epitopes and may contribute to the development of biologics with lower immunogenic potential.

Abzena’s authors include our Chief Scientific Officer, Dr Campbell Bunce, and Director of Immunology, Dr Edward Cloake.

Access the journal publication by clicking here.

Citation: Jankowski W, Kidchob C, Bunce C, Cloake E, Resende R and Sauna ZE (2023) The MHC Associated Peptide Proteomics assay is a useful tool for the non-clinical assessment of immunogenicity. Front. Immunol. 14:1271120. doi: 0.3389/fimmu.2023.1271120

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