Driving Predictive Science Forward: Inside the Shift Toward Human-Relevant Drug Discovery

When Jeroen de Groot joined Ncardia in 2024, he stepped into a moment that many in drug discovery have been anticipating but few have navigated well. The industry has spent decades refining animal models, adjusting protocols, and searching for signals that would bring preclinical data closer to clinical reality. The limits of that approach have become increasingly difficult to ignore. Human biology, it turns out, is the only reliable proxy for human outcomes.